E. Danelius

Eliminating the missing cone challenge through innovative approaches

This paper demonstrates that suspended drop crystallization eliminates the missing cone challenge in MicroED for thin plate crystals.

Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED

This paper reports two polymorphic crystal structures of paritaprevir determined by MicroED, showing conformational changes and potential drug-target interactions.

MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations

This study uses MicroED to rapidly determine atomic structures of flexible macrocyclic drug compounds from nanogram samples, revealing multiple conformations from a single experiment.

MicroED structure of a protoglobin reactive carbene intermediate

The paper determines the MicroED structure of an Aeropyrum pernix protoglobin variant, revealing how mutations enhance carbene transfer activity and stabilize a reactive iron-carbenoid intermediate.