G. Bu

An Updated Structure of Oxybutynin Hydrochloride

This study determines the 3D structure of oxybutynin hydrochloride using MicroED and reveals insights into its binding mechanism with the M3 muscarinic receptor.

Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants

This study uses MicroED and molecular docking to determine the atomic structures and binding mechanisms of five common antidepressants from commercial powder samples.

Eliminating the missing cone challenge through innovative approaches

This paper demonstrates that suspended drop crystallization eliminates the missing cone challenge in MicroED for thin plate crystals.

MicroED structure of the C11 cysteine protease Clostripain

This paper determines the structure of Clostripain using MicroED, revealing its catalytic dyad and substrate binding pocket.

Co-transcriptional translation amplifies mRNA noise in Escherichia coli

This study shows co-transcriptional translation in E. coli increases mRNA noise by amplifying transcriptional variability and altering bursting kinetics.

Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED

This paper reports two polymorphic crystal structures of paritaprevir determined by MicroED, showing conformational changes and potential drug-target interactions.

MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations

This study uses MicroED to rapidly determine atomic structures of flexible macrocyclic drug compounds from nanogram samples, revealing multiple conformations from a single experiment.

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

This study shows that APOE deficiency in human iPSC-derived cerebral organoids disrupts lipid homeostasis and affects cholesterol biosynthesis and neurogenesis.

Structure determination from lipidic cubic phase embedded microcrystals by MicroED

This study demonstrates the use of modified LCP and MicroED protocols to determine structures from microcrystals embedded in LCP using proteinase K as a model system.