Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy
E. S. King, A. E. Stacy, D. T. Weaver, J. A. Maltas, R. Barker-Clarke, E. Dolson, J. G. Scott
The paper introduces a fitness seascape model to study drug resistance in E. coli by mapping genotypes to dose-response functions and shows that higher mutation supply and early drug adherence reduce resistance.
bioRxiv · Jun 10, 2022Evolutionary Biology