N. Krishnan

A BCG Skin Challenge Model for Assessing TB Vaccines

This paper develops a BCG skin challenge model to assess TB vaccines using non-invasive imaging and shows vaccination reduces fluorescence, indicating immune response.

Phenotypic plasticity shapes biofilm's structure and fluid transport enhancing resilience

The paper investigates how phenotypic plasticity in Bacillus subtilis biofilms enhances resilience through spatial organization and fluid transport properties.

Vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation.

This study shows vimentin supports cell polarization by enhancing centrosome function and microtubule acetylation in mouse embryonic fibroblasts.

Coevolutionary Stability of Host-Symbiont Systems with Mixed-mode Transmission

The paper analyzes the coevolutionary stability of host-symbiont systems with mixed-mode transmission, showing how symbiont effects on host life history parameters influence long-term growth rates and evolutionary stability.

Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during Zebrafish Left-Right Organizer development

The paper shows Rab8, Rab11, and Rab35 coordinate membrane trafficking to synchronize cilia and lumen formation in zebrafish left-right organizer development.

Genesis of Ecto-symbiotic features based on Commensalistic Syntrophy

This study explores the evolutionary origin of ecto-symbiotic features through a commensalistic syntrophy model, hypothesizing a single mutation initiated host-symbiont interactions.

BRCA1 Hypermethylation In Sporadic Breast Cancers: Discovering A Novel Pathway To Tumorigenesis Via Coordinate NBR2 Deregulation And TNBC Transformation

This study identifies a novel pathway in sporadic breast cancers where BRCA1 hypermethylation leads to NBR2 deregulation, TNBC transformation, and aggressive tumor behavior through altered transcript ratios and hormone receptor dynamics.

Lipid mediated inhibition of Niemann-Pick C1 protein is an evolutionary conserved feature of multiple Mycobacterium lineages and non-tubercular mycobacteria.

This study investigates whether lipid extracts from various mycobacterial strains inhibit the NPC1 pathway, finding that inhibition occurs in most strains but not in Mycobacterium canettii.

Rab11 endosomes coordinate centrosome number and movement following mitotic exit

This study shows Rab11-endosomes regulate centrosome movement and abscission by controlling pericentrin organization in human and zebrafish cells.

A remarkably specific ligand reveals ghrelin O-acyltransferase interacts with extracellular peptides and exhibits unexpected cellular localization for a secretory pathway enzyme

This study identifies a specific ligand that shows GOAT interacts with extracellular ghrelin and facilitates its internalization, revealing new insights into its catalytic mechanism and signaling role.

Range expansion shifts clonal interference patterns in evolving populations

This study examines how range expansion affects clonal interference patterns in evolving populations, finding that mutant fixation dynamics vary with population size, mutation rate, and spatial structure.

Virus-host interactions shape viral dispersal giving rise to distinct classes of travelling waves in spatial expansions

This study shows that bacteriophage T7 exhibits density-dependent dispersal due to host interactions, leading to a transition from pulled to pushed reaction-diffusion waves in spatial expansions.

Controlling the speed and trajectory of evolution with counterdiabatic driving

This paper introduces a method to control evolutionary speed and trajectory using counterdiabatic driving, with applications in disease treatment and climate adaptation.