Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in BALB/c mice.
V. M. Dzul-Huchim, M. J. Ramirez-Sierra, P. P. Martinez-Vega, M. E. Rosado-Vallado, V. E. Arana-Argaez, J. Ortega-Lopez, F. Gusovsky, E. Dumonteil, J. V. Cruz-Chan, P. Hotez, M. E. Bottazzi, L. E. Villanueva Lizama
This study shows that combining low-dose benznidazole with a bivalent recombinant protein vaccine reduces cardiac fibrosis in mice infected with Trypanosoma cruzi.
bioRxiv · Feb 16, 2022Immunology