This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

bioRxiv · Feb 26, 2024 · PreprintMicrobiology

First-in-class Transactivator-Free, Doxycycline-inducible IL-18-engineered CAR-T cells for relapsed/refractory B-cell lymphomas

P. L. Justicia-Lirio, M. Tristan-Manzano, N. Maldonado-Perez, C. Barbero-Jimenez, M. Cortijo-Gutierrez, K. Pavlovic, F. J. Molina-Estevez, P. Munoz, A. Hinckley-Boned, C. Grinan-Lison, S. A. Navarro-Marchal, J. Munoz-Ballester, P. A. Gonzalez-Sierra, C. Herrera, J. A. Marchal, F. Martin

This paper develops doxycycline-inducible IL-18 CAR-T cells (iTRUCK19.18) that enhance antitumor activity while controlling IL-18 release through dual mechanisms.

bioRxiv · Jan 23, 2024 · PreprintImmunology

Bacterial Microbiome and Host Inflammatory Gene Expression in Foreskin Tissue

B. S. Maust, S. Petkov, C. Herrera, C. Feng, B. P. Brown, L. Lebina, D. Opoka, A. Ssemata, N. Pillay, J. Serwanga, P. Seatlholo, P. Namubiru, G. Odoch, S. Mugaba, T. Seiphetlo, , the CHAPS team

The paper analyzes the foreskin microbiome and host gene expression in adolescents from South Africa and Uganda, finding no treatment effect on bacterial communities but inverse correlations between bacterial abundance and inflammatory gene expression.

bioRxiv · Aug 29, 2022Microbiology

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

S. A. Banse, E. G. Jackson, C. A. Sedore, B. Onken, D. Hall, A. L. Coleman-Hulbert, P. Huynh, T. Garrett, E. Johnson, G. Harinath, D. Inman, S. Guo, M. Morshead, J. Xue, R. Falkowski, , P. C. Phillips

This study evaluates how compound interventions and genetic background affect healthspan and lifespan in C. elegans under stress conditions.

bioRxiv · Jan 15, 2022Physiology

NMR spectroscopy of a single mammalian embryo

G. Sivelli, G. M. Conley, C. Herrera, K. Marable, K. Rodriguez, H. Bollwein, M. Sudano, J. Brugger, A. Simpson, G. Boero, G. Marco

This study demonstrates the use of ultra-compact NMR probes to detect and resolve NMR signals from individual bovine embryos, revealing spectral variations despite similar morphology.

bioRxiv · Jul 26, 2021 · PreprintBiochemistry

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

A.-K. Reuschl, M. Shivkumar, D. Mesner, L. J. Pallett, J. A. Guerra-Assuncao, R. Madansein, K. J. Dullabh, A. Sigal, J. P. Thornhill, C. Herrera, S. Fidler, M. Noursadeghi, M. Maini, C. Jolly

This study shows HIV-1 infects resting memory T cells without prior activation, inducing a tissue-resident memory-like phenotype driven by Vpr.

bioRxiv · Jan 25, 2021Microbiology

Polymorphism and selection pressure of SARS-CoV-2 vaccine and diagnostic antigens: implications for immune evasion and serologic diagnostic performance

E. Dumonteil, C. Herrera

The paper analyzes SARS-CoV-2 antigen diversity and selection pressure, finding emerging clades and diversifying selection that may impact diagnostic and vaccine effectiveness.

bioRxiv · Jun 18, 2020Microbiology

A novel role of VisP and Wzz system during O-antigen assembly in Salmonella Typhimurium pathogenesis

P. da Silva, F. Z. Manieri, C. Herrera, M. S. Trent, C. G. Moreira

This paper identifies VisP as a novel protein involved in O-antigen biosynthesis in Salmonella Typhimurium and shows how O-antigen length affects bacterial pathogenesis.

bioRxiv · May 9, 2018Microbiology