Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes
T. C. Chamberlain, S. T. Cheung, J. S. J. Yoon, A. Ming-Lum, B. R. Gill, S. Shakibakho, E. Dzananovic, F. Ban, A. Samiea, K. Jawanda, J. Priatel, G. Krystal, C. J. Ong, A. Cherkasov, R. J. Andersen, , A. L.-F. Mui
The paper shows IL10 induces a SHIP1/STAT3 complex in macrophages, and SHIP1 activators mimic IL10's anti-inflammatory effects in colitis.
bioRxiv · May 29, 2020Immunology