Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture
E. Ergir, J. Oliver-de la Cruz, S. Fernandes, M. Cassani, F. Niro, D. Sousa, J. Vrbsky, V. Vinarsky, A. R. Perestrelo, D. Debellis, F. Cavalieri, S. Pagliari, H. Redl, P. Ertl, G. Forte
This study develops a scaffold-free protocol to generate long-term beating human cardiac organoids from hiPSCs, showing improved maturation and functionality for drug testing and cardiotoxicity studies.
bioRxiv · Mar 7, 2022 · PreprintCell Biology