G. Forte

An iPSC-derived bio-inspired scaffold modelling the structure and the effects of extracellular matrix in cardiac fibrosis

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.

TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

This study shows TGF-β signaling drives ECM changes and EMT in prostate cancer tumoroids, promoting tumor progression.

YAP signaling regulates the cellular uptake and therapeutic effect of nanoparticles

This study shows that inhibiting YAP enhances nanoparticle uptake in triple-negative breast cancer cells, suggesting YAP targeting could improve nanotherapy effectiveness.

Cluster size determines internal structure of transcription factories in human cells

This study develops a chromatin polymer model to show that cluster size determines whether transcription factories are specialised or mixed, reconciling conflicting experimental results.

Bridging-mediated compaction of mitotic chromosomes

This paper uses simulations to show bridging factors create mitotic-like chromosome structures without energy input, matching experimental observations.

Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture

This study develops a scaffold-free protocol to generate long-term beating human cardiac organoids from hiPSCs, showing improved maturation and functionality for drug testing and cardiotoxicity studies.

Transcription modulates chromatin dynamics and locus configuration sampling

The paper uses simulations and experiments to show transcription affects chromatin dynamics and locus configurations in mouse cells.

The mechanical regulation of RNA binding protein hnRNPC in the failing heart

The paper shows that hnRNPC upregulation and relocation to the Z-disk in failing hearts affects mRNA alternative splicing and mechanotransduction.

Core Fermentation (CoFe) granules focus coordinated glycolytic mRNAlocalization and translation to fuel glucose fermentation

The paper identifies Core Fermentation (CoFe) granules in yeast and human cells that localize and translate glycolytic mRNAs to support glucose fermentation.

Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth

The paper shows that translation factor mRNAs form granules transported to yeast daughter cells, enhancing protein synthesis at growth tips.