S. Fernandes

Regulation of cell-nanoparticle interactions through mechanobiology

This study shows that inhibiting the Hippo pathway component yes-associated protein increases nanoparticle internalization in cancer cells, independent of nanoparticle or cell properties.

Modulation of Microtubule Dynamics by Monovalent Ions

This study examines how four monovalent ions affect microtubule dynamics in vitro, revealing distinct effects with Na+ destabilizing and Ac- stabilizing microtubules.

ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

This study shows ERK3 promotes TNBC progression through EMT plasticity and collective migration, linking it to poor clinical outcomes.

An iPSC-derived bio-inspired scaffold modelling the structure and the effects of extracellular matrix in cardiac fibrosis

This paper develops a bio-inspired scaffold from iPSC-derived cardiac myofibroblasts to model fibrotic ECM effects on cardiomyocytes.

Moonlight synchronous flights across three western palearctic swifts mirror size dependent prey preferences

The paper analyzes flight behavior of three swift species in response to moonlight and finds size-dependent prey preferences influence flight height adjustments.

TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

This study shows TGF-β signaling drives ECM changes and EMT in prostate cancer tumoroids, promoting tumor progression.

YAP signaling regulates the cellular uptake and therapeutic effect of nanoparticles

This study shows that inhibiting YAP enhances nanoparticle uptake in triple-negative breast cancer cells, suggesting YAP targeting could improve nanotherapy effectiveness.

Importance of genetic architecture in marker selection decisions for genomic prediction

This study evaluates how genetic architecture affects prediction accuracy when using SNPs or SVs for genomic prediction across multiple environments.

Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination

This study uses chemical synthesis to create tubulins with defined PTMs, revealing that polyglutamylation promotes detyrosination by enhancing vasohibin/SVBP activity.

Generation and Maturation of Human iPSC-derived Cardiac Organoids in Long Term Culture

This study develops a scaffold-free protocol to generate long-term beating human cardiac organoids from hiPSCs, showing improved maturation and functionality for drug testing and cardiotoxicity studies.

Phenotyping stomatal closure by thermal imaging for GWAS and TWAS of water use efficiency-related genes

Rapid phenotyping of 659 Sorghum bicolor accessions revealed heritable stomatal responses to light decrease. GWAS/TWAS identified candidate genes influencing water-use efficiency traits.

Motor usage imprints microtubule stability in the shaft

The paper shows that molecular motor activity on microtubules increases their average length and densifies the network, influencing cell polarity through dimer exchange along the shaft.

Machine learning enabled phenotyping for GWAS and TWAS of WUE traits in 869 field-grown sorghum accessions

This study uses machine learning and phenotyping to identify 394 genes associated with water use efficiency traits in sorghum through GWAS and TWAS of 869 field-grown accessions.

Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin

The paper examines how sedimentation rates and organic matter dynamics influence microbiome structure and function in different oxygen minimum zones along the Arabian Sea margin.

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

This study shows that pan-SHIP1/2 inhibition prevents diet-induced obesity and improves glucose regulation, but requires eosinophils for fat reduction and acts via the VAT immune compartment.

Metabolically-active obligate aerobes in anoxic (sulfidic) marine sediments

The paper identifies metabolically-active obligate aerobes in anoxic marine sediments by combining culture-dependent and -independent methods, revealing their survival through cryptic oxygen production.

Cryptic role of tetrathionate in the sulfur cycle: A study from Arabian Sea oxygen minimum zone sediments

The paper investigates the role of tetrathionate in the sulfur cycle of Arabian Sea OMZ sediments, revealing its microbial and geochemical sources and transformations.

Inorganic salts and compatible solutes help mesophilic bacteria inhabit the high temperature waters of a Trans-Himalayan sulfur-borax spring

The paper investigates how inorganic salts and compatible solutes enable mesophilic bacteria to thrive in high-temperature Trans-Himalayan hot springs by stabilizing macromolecules and maintaining cell viability.