Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth
A. Dick, M. J. Reginato, J. Beld, N. L. Simone, S. Cocklin, A. A. Rashad, A. N. Talarico, J. Merzy, R. G. Young, L. Ciraku, E. Esquea
This study identifies and validates two novel ACSS2 inhibitors that cross the blood-brain barrier and reduce breast cancer brain metastasis in vitro and ex vivo.
bioRxiv · Dec 22, 2023 · PreprintCancer Biology