Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma
C. Gerard, M. Di-Luoffo, L. Gonay, S. Caruso, G. Couchy, A. Loriot, J. Tao, K. Konobrocka, S. Cordi, S. P. Monga, E. Hanert, J. Zucman-Rossi, F. P. Lemaigre
The paper identifies and models a gene regulatory network linking LIN28B-dependent dedifferentiation with CTNNB1 dysfunction in HCC, predicting drug response and cell state dynamics.
bioRxiv · Jun 15, 2018Cancer Biology