Author

A. Loriot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. P. Lemaigre· 3 shared A. Diacofotaki· 2 shared C. De Smet· 2 shared C. Gerard· 2 shared K. Konobrocka· 2 shared M. Di-Luoffo· 2 shared M. Komuta· 2 shared N. Dauguet· 2 shared

Activity by Year

2018-2024 · peak 1/yr

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10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

F. P. Lemaigre

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6 papers

Recent·Most cited

Spatial transcriptomics profiling of gallbladder adenocarcinoma: a detailed two-case study of progression from precursor lesions to cancer

S. Pirenne, F. Manzano-Nunez, A. Loriot, S. Cordi, L. Desmet, S. Aydin, C. Hubert, S. Toffoli, N. Limaye, C. Sempoux, M. Komuta, L. Gatto, F. P. Lemaigre

This study uses spatial transcriptomics to analyze two gallbladder cancer patients, showing distinct progression paths and the role of SEMA4A repression in tumor development.

bioRxiv · Feb 27, 2024Cancer Biology

An abundance of brain-expressed genes show ectopic activation in lung adenocarcinoma

A. Diacofotaki, A. Loriot, C. De Smet

The paper identifies brain-expressed genes (CB genes) and brain-testis genes (CBT genes) that are aberrantly activated in lung adenocarcinoma and other tumor types, suggesting a brain gene expression program contributes to malignancy.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

BRAFV600E expression in thyrocytes causes recruitment of immunosuppressive STABILIN-1 macrophages

C. Spourquet, O. Delcorte, P. Lemoine, N. Dauguet, A. Loriot, Y. Achouri, M. Hollmen, S. Jalkanen, F. Huaux, S. Lucas, P. Van Meerbeeck, J. Knauf, J. A. Fagin, C. Dessy, M. Mourad, , C. E. Pierreux

This study shows that BRAFV600E expression in thyrocytes recruits immunosuppressive STABILIN-1 macrophages in a mouse model of papillary thyroid carcinoma, with similar findings in human thyroid tissues.

Cancers · Sep 26, 2022Peer-reviewedCancer Biology

Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer

J. S. Fain, A. Loriot, A. Diacofotaki, A. Van Tongelen, C. De Smet

The paper shows that DNA hypomethylation in tumors can lead to hypermethylation of adjacent promoters through overlapping transcription, linking two opposite epigenetic changes in cancer.

bioRxiv · May 21, 2021Cancer Biology

A novel mouse model of cholangiocarcinoma uncovers a role for a SOX17-Tensin 4 pathway in tumor progression

M. Di-Luoffo, S. Pirenne, T. Saandi, A. Loriot, C. Gerard, N. Dauguet, F. Lamoline, K. Konobrocka, V. De Greef, M. Komuta, P. Jacquemin, F. P. Lemaigre

This study develops a mouse model of intrahepatic cholangiocarcinoma (iCCA) and identifies a SOX17-Tensin 4 pathway that promotes tumor progression.

bioRxiv · Dec 31, 2019 · PreprintCancer Biology

Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma

C. Gerard, M. Di-Luoffo, L. Gonay, S. Caruso, G. Couchy, A. Loriot, J. Tao, K. Konobrocka, S. Cordi, S. P. Monga, E. Hanert, J. Zucman-Rossi, F. P. Lemaigre

The paper identifies and models a gene regulatory network linking LIN28B-dependent dedifferentiation with CTNNB1 dysfunction in HCC, predicting drug response and cell state dynamics.

bioRxiv · Jun 15, 2018Cancer Biology