S. P. Monga

Lysosomal mitochondrial interaction promotes tumor growth in squamous cell carcinoma of the head and neck

This study shows that lysosomal-mitochondrial interaction (LMI) promotes tumor growth in squamous cell carcinoma of the head and neck by enhancing mitochondrial complex I activity and lysosomal function.

Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation

This study shows that reducing huntingtin in liver cells leads to metabolic changes, altered cell adhesion, and disrupted liver zonation patterns in mice.

Western diet unmasks transient low-level vinyl chloride exposure-induced tumorigenesis; potential role of the (epi-)transcriptome

This study shows that low-level vinyl chloride exposure combined with a Western diet increases liver cancer risk in mice through metabolic and epitranscriptomic changes.

Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease

This study shows that a western diet impairs T regulatory cell function in NAFLD, leading to chronic inflammation and fibrosis, and suggests restoring Treg function as a potential therapy.

Selective targeting of α4β7/MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver

This study shows that targeting the α4β7/MAdCAM-1 axis reduces proinflammatory T cell recruitment to the liver, thereby suppressing liver fibrosis progression in a mouse model.

A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liver

The paper maps the spatial expression of Wnt and Frizzled receptors in adult mouse liver, revealing zonation patterns and cell-type-specific expression.

Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

Deletion and overexpression of the scaffolding protein IQGAP1 promotes HCC

This study shows that both deletion and overexpression of IQGAP1 promote hepatocellular carcinoma (HCC) through distinct mechanisms.

Dynamics and predicted drug response of a gene network linking dedifferentiation with beta-catenin dysfunction in hepatocellular carcinoma

The paper identifies and models a gene regulatory network linking LIN28B-dependent dedifferentiation with CTNNB1 dysfunction in HCC, predicting drug response and cell state dynamics.