The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants
K. Rayani, E. Hantz, O. Haji-Ghassemi, A. Y. Li, A. M. Spuches, F. Van Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits
This study investigates how magnesium affects calcium binding to cardiac troponin C mutants linked to hypertrophic cardiomyopathy, showing that Mg2+ competes with Ca2+ and modifies binding affinity.
bioRxiv · May 12, 2021 · PreprintCell Biology