S. Lindert

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development

This study investigates the pathogenic mechanisms of the TNNT2 R278C+/- variant in cardiomyocytes using proteomics and functional assays, revealing its impact on cardiac function and arrhythmia.

Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship

The paper investigates small molecules targeting troponin C to enhance calcium sensitivity in cardiac and skeletal muscle without altering systolic calcium levels, identifying a potent sensitizer with an apparent affinity of 117 ± 17 M.

Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling

This paper introduces a hybrid method combining AlphaFold and Rosetta with covalent labeling data to improve protein complex structure prediction.

Validated Determination of NRG1 Ig-like Domain Structure by Mass Spectrometry Coupled with Computational Modeling

The paper uses HR-HRPF-based modeling to determine the structure of NRG1 Ig-like domain, validating it against NMR results.

Protein shape sampled by ion mobility mass spectrometry consistently improves protein structure prediction

This study shows that ion mobility mass spectrometry data improve protein structure prediction using Rosetta, achieving better accuracy for 15 out of 23 benchmark proteins.

The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants

This study investigates how magnesium affects calcium binding to cardiac troponin C mutants linked to hypertrophic cardiomyopathy, showing that Mg2+ competes with Ca2+ and modifies binding affinity.

Binding of Calcium and Magnesium to Cardiac Troponin C

This study quantifies Ca2+/Mg2+ binding to cardiac troponin C site II, showing Mg2+ can occupy site II and reduce Ca2+ affinity at physiological concentrations.