TRB3 augments IL1β-TLR4 signaling by engaging Flightless-homolog 1.
S. Gonuguntla, R. K. Humphrey, A. Gorantla, E. Hao, U. S. Jhala
This study shows TRB3 enhances IL1β-TLR4 signaling by interacting with Fli1 to release MyD88, promoting proinflammatory responses in beta cells.
bioRxiv · Oct 9, 2022 · PreprintBiochemistry