Redox-mediated inactivation of the transcriptional repressor C3600 makes uropathogenic Escherichia coli exquisitely resistant to reactive chlorine species
S. Sultana, K. LeDoux, M. E. Crompton, O. Jankiewicz, G. H. Morales, C. Johnson, E. Horbach, K. P. Hoffmann, P. KR, R. Shah, G. M. Anderson, N. T. Mortimer, J. E. Schmitz, M. Hadjifrangiskou, A. Foti, J.-U. Dahl
This study identifies a redox-mediated mechanism in UPEC that enhances resistance to HOCl by inactivating the transcriptional repressor C3600 through disulfide bond formation.
bioRxiv · Aug 31, 2021 · PreprintMicrobiology