C. Johnson

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

A drug cocktail of rapamycin, acarbose, and phenylbutyrate enhances resilience to features of early-stage Alzheimer's disease in aging mice

Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

The paper identifies inter-individual transcriptional correlations across metabolic tissues to infer signaling mechanisms, validating findings with known biological roles.

Phase diversity-based wavefront sensing for fluorescence microscopy

This paper introduces a phase diversity-based wavefront sensing method for fluorescence microscopy to correct optical aberrations efficiently and accurately.

Uncovering Hidden Data in the AMNH Marine Invertebrate Collections

The paper analyzes historic marine crustacean data from museum specimens to understand historical abundance and distribution in relation to ocean temperature changes.

Pseudomonas aeruginosa kills Staphylococcus aureus in a polyphosphate-dependent manner

This study shows Pseudomonas aeruginosa kills Staphylococcus aureus via polyphosphate-dependent mechanisms, primarily through polyP-regulated pyocyanin production.

Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.

Locally low-rank denoising in transform domains

This paper extends locally low-rank denoising techniques to transform domains, improving MR image denoising with fewer images.

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response

The paper presents a spatially resolved single-cell atlas of lung tissue from fatal Covid19 cases in an African population, revealing a distinct cellular signature and an interferon gamma-dominated response.

Molecular subtypes of high grade serous ovarian cancer across racial groups and gene expression platforms

This study identifies molecular subtypes of high-grade serous ovarian cancer across racial groups and gene expression platforms, finding similar subtype-specific survival rates despite differences in subtype prevalence.

EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice

This study shows EZH2 deletion in adult acinar cells does not block regeneration but limits PDAC progression by altering the tumor microenvironment and differentiation.

Beclin1 is essential for intestinal homeostasis.

This study shows BECLIN1 is critical for intestinal homeostasis, as its deletion in adult mice causes fatal enteritis with compromised gut barrier integrity and morphological abnormalities.

Expression of RcrB confers resistance to hypochlorous acid in uropathogenic Escherichia coli

This study identifies RcrB as a key protein conferring resistance to hypochlorous acid in uropathogenic Escherichia coli, showing its protective role against RCS but not ROS.

TGF-β1 activates neutrophil signaling and gene expression but not migration

This study shows TGF-β1 activates neutrophil signaling pathways but not migration, and induces gene expression changes in HL-60 cells.

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer

This study investigates how nutrient supply affects ASNS and GPER1 expression in KRAS mutant and wild-type colorectal cancer cells and their association with patient survival.

Virally induced lipid droplets are a platform for innate immune signalling complexes

This study shows that virally induced lipid droplets host antiviral signaling proteins and undergo dynamic proteome and lipidome changes to support innate immune responses.

GPR41/43 regulates blood pressure by improving gut epithelial barrier integrity to prevent TLR4 activation and renal inflammation

This study shows that GPR41/43 receptors regulate blood pressure by maintaining gut barrier integrity and preventing renal inflammation through TLR4 signaling.

Discovery and characterization of non-canonical E2 conjugating enzymes

The paper identifies and characterizes non-canonical E2 conjugating enzymes that ubiquitylate serine and threonine instead of lysine, revealing their target substrate and catalytic mechanism.

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge

This study shows cytokine-induced degradation of ERG in lung endothelial cells leads to vascular hyperpermeability and inflammation during infection.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

Comprehensive approach to study branched ubiquitinchains reveals roles for K48-K63 branches inVCP/p97-related processes

This paper develops a pipeline to study branched ubiquitin chains, identifies debranching enzymes, and reveals their roles in VCP/p97 processes and DNA damage responses.

Extensive collagen deposition by mesenchymal stem cells cultured in 3D self-assembled peptide scaffolds as revealed by nanoplasmonic colorimetric histology.

The paper investigates collagen deposition by mesenchymal stem cells in 3D peptide scaffolds and introduces a label-free method to image collagen.

Mass extravasation and tubular uptake of red blood cells results in toxic injury to the tubules during kidney ischemia from venous clamping

This study shows that venous clamping in rats causes severe kidney tubular injury due to red blood cell extravasation and uptake, which is absent in blood-free kidneys.

Maternal diet and gut microbiota influence predisposition to cardiovascular disease in the offspring

The paper shows that maternal fibre intake during pregnancy influences offspring cardiovascular health by shaping the gut microbiome and inducing epigenetic changes in the offspring's heart.

Realtime morphological characterization and sorting of unlabeled viable cells using deep learning

COSMOS enables real-time, unlabeled cell sorting based on morphology using deep learning, achieving high enrichment of viable cells for functional analysis.

Genetic variation of human myokine signaling is dominated by biologic sex and sex hormones

This study investigates the genetic regulation of myokine signaling in humans, finding that biologic sex and sex hormones, particularly estrogens, dominate its variation across tissues.

Structural Basis for an Unprecedented Enzymatic Alkylation in Cylindrocyclophane Biosynthesis

This paper determines the structure and mechanism of the cyanobacterial enzyme CylK, which performs unique alkylation reactions in cylindrocyclophane biosynthesis.

Progressive protein aggregation in PRPF31 patient retinal pigment epithelium cells: the mechanism and its reversal through activation of autophagy

This study shows that PRPF31 mutations cause progressive protein aggregation in RPE cells, which can be reversed by autophagy activation.

Redox-mediated inactivation of the transcriptional repressor C3600 makes uropathogenic Escherichia coli exquisitely resistant to reactive chlorine species

This study identifies a redox-mediated mechanism in UPEC that enhances resistance to HOCl by inactivating the transcriptional repressor C3600 through disulfide bond formation.