Disruption of DLL4/NOTCH1 Causes Dysregulated PPARγ/AKT Signaling in Pulmonary Arterial Hypertension
K. S. Awad, S. Wang, E. J. Dougherty, A. Keshavarz, C. Y. Demirkale, Z.-X. Yu, L. Miller, J. M. Elinoff, R. L. Danner
This study shows that DLL4/NOTCH1 signaling regulates PPARγ/AKT pathways in PAH, with potential therapeutic implications for vascular remodeling.
bioRxiv · Jan 31, 2024Cell Biology