L. Miller

Disruption of DLL4/NOTCH1 Causes Dysregulated PPARγ/AKT Signaling in Pulmonary Arterial Hypertension

This study shows that DLL4/NOTCH1 signaling regulates PPARγ/AKT pathways in PAH, with potential therapeutic implications for vascular remodeling.

WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

nELISA enables high-throughput, high-plex protein profiling of the inflammatory secretome, revealing 447 significant cytokine responses across multiple donors and conditions.

Cerebral malaria is regulated by host mediated changes in Plasmodium gene expression

The paper shows that Plasmodium ANKA parasites exhibit ECM-specific gene expression profiles that are activated only in susceptible hosts, indicating host influence on cerebral malaria outcomes.

Dynamics and Energetics of Bottlenose Dolphins (Tursiops truncatus) Fluke-and-Glide Gait

This paper models the fluke-and-glide gait of bottlenose dolphins and finds it reduces metabolic and mechanical costs of transport compared to continuous fluking.

Distinct upper airway epithelium interferon-stimulated and profibrotic gene expression between adult and infant rhesus macaques infected with SARS-CoV-2

This study compares SARS-CoV-2 infection effects in adult and infant rhesus macaques, finding distinct interferon-stimulated and profibrotic gene expression patterns in upper airway epithelium.

Balance between protective and pathogenic immune responses to pneumonia in the neonatal lung enforced by gut microbiota.

The paper shows that gut microbiota balance immune responses in neonatal lungs, promoting recovery from pneumonia by modulating tissue repair and inflammation.

Vision-based monitoring and measurement of bottlenose dolphins' daily habitat use and kinematics

This paper uses computer vision to track bottlenose dolphins and analyze their habitat use and kinematics in a managed environment.

FRET and LRET Biosensors for Cell-based Imaging and Screening of Rac1 Activation

This paper develops FRET and LRET biosensors with ER/K linkers to image and screen Rac1 activation in cells, showing enhanced dynamic range and small molecule inhibition detection.

The intensity of the immune response to LPS and E. coli regulates the induction of preterm labor in Rhesus Macaques

This study shows that live E. coli induces stronger immune responses, including higher IL6 and prostaglandin levels, leading to preterm labor in Rhesus macaques compared to LPS.

ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation

This study shows ESR1 mutant breast cancers exhibit basal cytokeratin expression and immune activation, linked to chromatin reprogramming and paracrine signaling.

The Utilization of Advance Telemetry to Investigate Important Physiological Parameters Including Electroencephalography in Cynomolgus Macaques Following Aerosol Challenge with Eastern Equine Encephalitis Virus

This study uses advanced telemetry in cynomolgus macaques to monitor physiological parameters after EEEV aerosol challenge, revealing severe alterations in cardiac and neurological functions leading to euthanasia.

Genomic landscape of tumor-host interactions with differential prognostic and predictive connotations

The paper analyzes tumor-host interactions across 31 cancer types using the ICR signature to identify prognostic and predictive implications of immune phenotypes.

Platelet-neutrophil aggregates promote skin pathology in psoriasis

This study identifies platelet-neutrophil aggregates as contributors to psoriasis skin pathology and disease severity.

A Fixed Moderate-dose Combination of Tiletamine+Zolazepam Outperforms Midazolam in Induction of Short-term Immobilization of Ball Pythons (Python regius)

This study compares the effectiveness of tiletamine+zolazepam and midazolam in anesthetizing ball pythons, finding that the combination provides more reliable immobilization.

NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody dependent cellular cytotoxicity

The paper shows that antibodies from malaria-exposed individuals activate NK cells to lyse infected red blood cells and inhibit parasite growth via ADCC.

NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

This study identifies NuMA as a negative regulator of 53BP1, showing it prevents 53BP1 accumulation at DNA breaks and influences repair outcomes.

Modular assembly of the nucleolar large subunit processome

The paper determines cryo-EM structures of the nucleolar large subunit processome in different states, revealing how assembly factors prevent premature folding and enable distinct folding pathways.

Morphological plant modeling: Unleashing geometric and topological potential within the plant sciences

This paper discusses the importance of mathematical modeling in plant morphology and outlines challenges and opportunities for integrating geometric and topological approaches in plant science research and education.