PARP inhibition causes premature loss of cohesion in cancer cells
E. Kukolj, T. Kaufmann, A. E. Dick, R. Zeillinger, D. W. Gerlich, D. Slade
This study shows PARP inhibition causes premature cohesion loss in cancer cells during mitosis, leading to sister chromatid scattering, and identifies PARP1/2 entrapment at replication forks as a mechanism.
bioRxiv · Jun 22, 2017Cell Biology