Author

T. Kaufmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

A. E. Dick· 1 shared D. Slade· 1 shared D. W. Gerlich· 1 shared E. Kukolj· 1 shared H. Wajant· 1 shared J. Knop· 1 shared L. M. Spilgies· 1 shared L. Vasilikos· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. E. Dick

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Author profile →

3 papers

Recent·Most cited

Electrostatic and bending energies predict staggering and splaying in nonmuscle myosin II minifilaments

T. Kaufmann, U. S. Schwarz

The paper uses electrostatics and elasticity theory to predict dynamic behaviors of nonmuscle myosin II minifilaments, showing parallel staggers lead to splaying and stable antiparallel staggers initiate nucleation.

PLOS Computational Biology · Jul 6, 2020Peer-reviewedBiophysics

TNFR2 induced priming of NLRP3-inflammasome via RIPK1 leads to pyroptosis in XIAP deficient cells

J. Knop, L. M. Spilgies, S. Rufli, R. Reinhardt, L. Vasilikos, M. Yabal, P. J. Jost, H. Wajant, M. D. Robinson, T. Kaufmann, W. W.-L. Wong

The paper shows TNFR2 activation in XIAP-deficient cells leads to NLRP3 inflammasome priming and pyroptosis via RIPK1 and ROS, with implications for reducing IL-18 release in XLP-2 patients.

bioRxiv · Feb 15, 2019Immunology

PARP inhibition causes premature loss of cohesion in cancer cells

E. Kukolj, T. Kaufmann, A. E. Dick, R. Zeillinger, D. W. Gerlich, D. Slade

This study shows PARP inhibition causes premature cohesion loss in cancer cells during mitosis, leading to sister chromatid scattering, and identifies PARP1/2 entrapment at replication forks as a mechanism.

bioRxiv · Jun 22, 2017Cell Biology