GLUT1 inhibition blocks growth of RB1-positive Triple Negative Breast Cancer
Q. Wu, W. Alawi, G. Deblois, J. Cruickshank, S. Duan, E. L. Fernandes, J. Haight, S. A. Tonekaboni, A. Fortier, H. Kuasne, T. McKee, H. Mahmoud, S. Cameron, N. D. Artun, W. Chen, , C. H. Arrowsmith
This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.
bioRxiv · Sep 11, 2019Cancer Biology