Q. Wu

Oral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice

This study shows oral K3Citrate reduces disc calcification in LG/J mice without affecting bone structure or locomotion, suggesting Ca2+ chelation as a potential mechanism.

The penetration ring is a novel infection structure formed by the penetration peg for invading plant cell membrane in rice blast fungus

This paper identifies a novel penetration ring formed by secreted proteins in the rice blast fungus after cell wall penetration, which persists at the plasma membrane interface during invasion.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds

The paper examines how habitat fragmentation influences climate-driven changes in bird communities over time, finding that fragmentation affects colonization and extinction rates of warm- and cold-adapted species.

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir

This study identifies TAC3 and its homologues as transcriptional co-activators that regulate age-dependent floral transition by modulating miR156 expression in Arabidopsis and Chinese fir.

Efficient cloning of genes for wheat yield component traits from QTLs via sequencing of the RIL population

This study develops a method to clone genes for wheat yield traits by sequencing RIL populations, identifying and validating 11 candidate genes from 77 QTLs.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

Immunosuppressive tumor microenvironment of osteosarcoma

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

Addressing preferred orientation in single-particle cryo-EM through AI-generated auxiliary particles.

This paper introduces cryoPROS, an AI method to address preferred orientation in cryo-EM, improving resolution without special experimental techniques.

AAV-HBV mouse model replicates immune exhaustion patterns of chronic HBV patients at single-cell level

Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity

The paper shows that actin-TFII-IΔ modulates ERK activity through cell height to direct cell fate during reprogramming.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

A common tolerance mechanism of bacterial biofilms to antibiotics

This study identifies a common mechanism by which bacterial biofilms resist antibiotics through lipid metabolism activation that reduces drug penetration and increases glucose consumption.

Rice potassium transporter OsHAK18 mediates phloem K+ loading and redistribution

This study identifies OsHAK18 as a phloem-localized K+ transporter that mediates K+ loading and redistribution in rice, enhancing shoot K+ retention under low-K+ stress.

Targeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen

This paper develops a targeted photodynamic approach to neutralize SARS-CoV-2 by enhancing antibody efficacy through singlet oxygen generation.

Structural basis for ubiquitylation by HOIL-1

This study determines the crystal structure of HOIL-1's C-terminal tandem domain, revealing its auto-inhibited conformation and the role of a unique bi-nuclear Zn-cluster in ubiquitylation.

Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing

The paper discovers a new aphid-transmitted rice virus, RTIV, from wild rice plants and shows it causes low-tillering disease in rice cultivars.

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation

This study identifies palmitate-rich metastatic niches as promoters of metastasis by enhancing p65 acetylation and NF-κB signaling in breast cancer cells.

Chi-miR-3880 mediates the regulatory role of interferon gamma in goat mammary gland

This study investigates the IFN{gamma}/chi-miR-3880/DDX58 axis in goat mammary gland lactation, showing its role in regulating proliferation, lipid formation, apoptosis, and involution through specific signaling pathways.

Global mosquito virome profiling and mosquito spatial diffusion pathways revealed by marker-viruses

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

Simultaneous transcriptome and proteome profiling in a single mouse oocyte with a deep single-cell multi-omics approach

The paper develops a single-cell multi-omics platform to simultaneously profile transcriptome and proteome in mouse oocytes, revealing transcriptome-proteome heterogeneity and identifying maturational signatures.

Spike-specific CXCR3+ TFH cells play a dominant functional role in supporting antibody responses in SARS-CoV-2 infection and vaccination

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

Serum response factor reduces gene expression noise and confers cell state stability

This study shows that Srf reduces gene expression noise and stabilizes cell state in mouse pluripotent stem cells by limiting developmental heterogeneity.

Pick-up Single-Cell Proteomic Analysis for Quantifying up to 3000 Proteins in a Tumor Cell

The paper develops PiSPA, a single-cell proteomic workflow, to quantify up to 3000 protein groups in tumor cells, demonstrating its utility in studying single-cell proteome dynamics.

TANKBind: Trigonometry-Aware Neural NetworKs for Drug-Protein Binding Structure Prediction

TANKBind improves drug-protein binding structure prediction by incorporating trigonometry constraints and functional block segmentation, achieving better performance than existing methods.