Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation
B. J. Tuck, L. V. C. Miller, E. L. Wilson, T. Katsinelos, S. Cheng, M. J. Vaysburd, C. Knox, L. Tredgett, E. Metzakopian, L. C. James, W. A. McEwan
The paper investigates how tau assemblies enter the cytosol, finding that cholesterol levels and specific cellular machinery are critical for this process, which is essential for seeded aggregation.
bioRxiv · Jun 21, 2021Cell Biology