Author

E. Metzakopian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Agrawal· 1 shared A. Barros· 1 shared A. Bradley· 1 shared A. Brown· 1 shared B. Fu· 1 shared B. J. Tuck· 1 shared C. Crapart· 1 shared C. Hockings· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCell Biology

A. Agrawal

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Author profile →

3 papers

Recent·Most cited

Tau assemblies enter the cytosol in a cholesterol sensitive process essential to seeded aggregation

B. J. Tuck, L. V. C. Miller, E. L. Wilson, T. Katsinelos, S. Cheng, M. J. Vaysburd, C. Knox, L. Tredgett, E. Metzakopian, L. C. James, W. A. McEwan

The paper investigates how tau assemblies enter the cytosol, finding that cholesterol levels and specific cellular machinery are critical for this process, which is essential for seeded aggregation.

bioRxiv · Jun 21, 2021Cell Biology

Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by slowing luminal transport

T. Konno, P. Parutto, D. M. D. Bailey, V. Davi, C. Crapart, M. A. Awadelkareem, C. Hockings, A. Brown, K. M. Xiang, A. Agrawal, J. E. Chambers, M. V. Werp, K. Koning, E. Metzakopian, L. Westrate, , E. Avezov

The paper shows RTN4/NOGO regulates ER morphology, which modulates luminal transport and Ca2+ delivery, affecting axonogenesis in neurons.

bioRxiv · May 10, 2021Cell Biology

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

G. Balmus, D. Pilger, J. Coates, M. Demir, M. Sczaniecka-Clift, A. Barros, M. Woods, B. Fu, F. Yang, E. Chen, M. Ostermaier, T. Stankovic, H. Ponstingl, M. Herzog, K. Yusa, , S. P. P. Jackson

The paper identifies how ATM counteracts toxic non-homologous end-joining at broken replication forks by showing that loss of NHEJ components or BRCA1-A complex confers resistance to DNA-damaging agents in ATM-deficient cells.

bioRxiv · May 24, 2018Cell Biology