T helper cell-licensed mast cells promote inflammatory Th17 cells
E. Leveque, R. Joulia, C. Petitfils, X. Mas-Orea, G. Payros, C. Laurent, N. Gaudenzio, G. Dietrich, S. Valitutti, N. Cenac, E. Espinosa
The paper shows that Th cells induce an inflammatory phenotype in mast cells, which in turn promote Th17 cells producing IFN-γ and GM-CSF via PGE2 and IL-1β.
bioRxiv · Jul 28, 2021 · PreprintImmunology