N. Gaudenzio

This study uses VaxSkin to analyze the skin's response to mRNA-1273 vaccine, showing targeted immune cell activation and communication.

This study identifies mast cell-derived BH4 as a key mediator of postoperative pain, showing that substance P triggers BH4-dependent serotonin release in mast cells, and blocking substance P reduces pain.

This paper introduces MANTIS, a tool for 3-D deconvolution of human skin immune architecture, revealing common immune features in severe skin conditions.

The paper shows that Th cells induce an inflammatory phenotype in mast cells, which in turn promote Th17 cells producing IFN-γ and GM-CSF via PGE2 and IL-1β.