Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions
E. Lettera, S. Scala, L. Basso-Ricci, T. Tavella, L. della Volpe, E. Lofurno, K. Kauffmann, L. Garcia-Prat, P. Quaranta, R. Hernandez, A. Murison, K. Giannetti, A. Aguilar-Navarro, S. Beretta, A. Conti, , R. Di Micco
The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.
bioRxiv · Sep 15, 2023 · PreprintCell Biology