Author

L. Garcia-Prat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Murison· 4 shared J. E. Dick· 4 shared M. Chan-Seng-Yue· 3 shared S. Z. Xie· 3 shared V. Voisin· 3 shared A. G. X. Zeng· 2 shared E. Wagenblast· 2 shared G. Krivdova· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

A. Murison

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia

I. Iacobucci, A. G. X. Zeng, Q. Gao, L. Garcia-Prat, P. Baviskar, S. Shah, A. J. Murison, V. Voisin, M. Chan-Seng-Yue, C. Cheng, C. Qu, C. Bailey, M. Lear, M. Witkowski, X. Zhou, , C. G. Mullighan

This study uses scRNA-seq to analyze B-ALL samples, revealing transcriptional heterogeneity and developmental origins, with specific subtypes associated with distinct cell populations and clinical outcomes.

bioRxiv · Dec 4, 2023Cancer Biology

Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

E. Lettera, S. Scala, L. Basso-Ricci, T. Tavella, L. della Volpe, E. Lofurno, K. Kauffmann, L. Garcia-Prat, P. Quaranta, R. Hernandez, A. Murison, K. Giannetti, A. Aguilar-Navarro, S. Beretta, A. Conti, , R. Di Micco

The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.

bioRxiv · Sep 15, 2023 · PreprintCell Biology

Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy

R. Marone, E. Landmann, A. Devaux, R. Lepore, D. Seyres, J. Zuin, T. Burgold, C. Engdahl, G. Capoferri, A. DellAglio, C. Larrue, F. Simonetta, J. Rositzka, M. Rhiel, G. Andrieux, , L. T. Jeker

This paper shows that epitope-engineered human hematopoietic stem cells are protected from CD123-targeted immunotherapy while maintaining functionality, offering a strategy for tumor-selective therapy.

bioRxiv · Jul 11, 2023Bioengineering

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing

T. Itkin, S. Houghton, R. Schreiner, Y. Lin, C. Badwe, V. Voisin, A. Murison, N. Seyedhassantehrani, K. B. Kaufmann, L. Garcia-Prat, G. T. Booth, F. Geng, Y. Liu, J. M. Gomez-Salinero, J.-H. Shieh, , S. Rafii

The paper identifies Fli-1's role in regulating HSC activation during regenerative hematopoiesis by enabling niche signaling and functional recovery.

bioRxiv · Mar 27, 2023 · PreprintCell Biology

Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

L. Garcia-Prat, K. B. Kaufmann, F. Schneiter, V. Voisin, A. Murison, J. Chen, M. Chan-Seng-Yue, O. I. Gan, J. L. McLeod, S. A. Smith, M. C. Shoong, D. Parris, K. Pan, A. G. X. Zeng, G. Krivdova, , J. E. Dick

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

bioRxiv · Feb 24, 2021 · PreprintCell Biology

Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

E. Wagenblast, J. Araujo, O. I. Gan, S. K. Cutting, A. Murison, G. Krivdova, M. Azkanaz, J. L. McLeod, S. A. Smith, S. A. Marhon, M. Gabra, M. Chan-Seng-Yue, L. Garcia-Prat, L. Salmena, D. D. D. De Carvalho, , E. R. Lechman

This study identifies the cellular origin and mechanisms of leukemia predisposition in Down syndrome by analyzing gene mutations and their effects in fetal hematopoietic cells.

bioRxiv · Nov 29, 2020Cancer Biology