Author

S. Scala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Aguilar-Navarro· 1 shared A. Aiuti· 1 shared A. Conti· 1 shared A. De Toma· 1 shared A. Murison· 1 shared A. Ronchi· 1 shared C. Camisaschi· 1 shared C. Chiodoni· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCell Biology

A. Aguilar-Navarro

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Author profile →

3 papers

Recent·Most cited

Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions

E. Lettera, S. Scala, L. Basso-Ricci, T. Tavella, L. della Volpe, E. Lofurno, K. Kauffmann, L. Garcia-Prat, P. Quaranta, R. Hernandez, A. Murison, K. Giannetti, A. Aguilar-Navarro, S. Beretta, A. Conti, , R. Di Micco

The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.

bioRxiv · Sep 15, 2023 · PreprintCell Biology

SDF-1/CXCR4 inhibition prevents paradoxical generation of cisplatin-induced pro-metastatic niches

G. Bertolini, V. Cancila, M. Milione, G. Lo Russo, O. Fortunato, N. Zaffaroni, M. Tortoreto, G. Centonze, C. Chiodoni, F. Facchinetti, F. Giovinazzo, M. Moro, C. Camisaschi, A. De Toma, C. D'Alterio, , L. Roz

This study shows that cisplatin promotes metastasis by creating pro-metastatic niches, which can be blocked by CXCR4 inhibition.

bioRxiv · Oct 26, 2020Cancer Biology

A cell-autonomous PD-1/PD-L1 circuit promotes tumorigenicity of thyroid cancer cells by activating a SHP2/Ras/MAPK signalling cascade

F. Liotti, N. Kumar, N. Prevete, M. Marotta, D. Sorriento, C. Ierano, A. Ronchi, F. Zito Marino, S. Moretti, R. Colella, E. Puxeddu, S. Paladino, Y. Kano, M. Ohh, S. Scala, R. M. Melillo

This study shows PD-1 in thyroid cancer cells promotes tumorigenicity via SHP2/Ras/MAPK signaling, and blocking this circuit inhibits tumor growth.

bioRxiv · Sep 22, 2020 · PreprintCancer Biology