Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart
B. Baggett, K. Murphy, E. Sengun, E. Mi, Y. Cao, N. Turan, Y. Lu, L. Schofield, T. Y. Kim, A. Kabakov, P. Bronk, Z. Qu, P. Camelliti, P. Dubielecka, D. Terentyev, , G. Koren
This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.
bioRxiv · Dec 21, 2021Cell Biology