K. Murphy

Flight-Scope: microscopy with microfluidics in microgravity

Flight-Scope enables live-cell imaging of dynamic processes in microgravity using microfluidics during parabolic flights, demonstrated with yeast glucose uptake.

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

This study shows BMI1 promotes erythroid self-renewal through both gene repression and activation, offering a strategy to expand immature erythroid precursors for clinical use.

Comprehensive Characterization of tRNA by Ultra High-Performance Liquid Chromatography High-Resolution Accurate Mass Spectrometry

The paper characterizes tRNA modifications using high-resolution mass spectrometry and identifies novel features in yeast tRNA.

Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis

This study shows that loss of intra-islet glucagon receptor signaling impairs glucose tolerance and insulin pulsatility in mice, suggesting glucagonergic agents could restore insulin pulsatility in T2D.

Bayesian species distribution models integrate presence-only and presence-absence data to predict deer distribution and relative abundance.

This paper applies Bayesian Integrated Species Distribution Models to empirical data to predict deer distribution and abundance using presence-absence and presence-only data in Ireland.

Characterisation and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry

This study develops an automated workflow for rapid characterization and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry.

EFA6R suppresses ovarian cancer cell migration and invasion

This study shows EFA6R expression is epigenetically downregulated in ovarian cancer, correlating with higher tumor grade and increased cell migration, independent of Arf6.

Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart

This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.

Measuring arterial pulsatility with Dynamic Inflow MAgnitude Contrast (DIMAC)

This paper introduces DIMAC, a new MRI method to measure real-time pulsatile flow in cerebral arteries, showing sensitivity to flow velocity and vascular tone changes.

The Vagus Nerve Mediates the Physiological but not Pharmacological Effects of PYY3-36 on Food Intake

This study shows that PYY3-36's physiological effects on food intake depend on the vagus nerve's Y2R, but pharmacological effects are not affected.

Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

The paper uses single-cell RNA sequencing to show that basal breast cancer cells mimic involution processes, involving interactions with the tumor microenvironment to promote progression.

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

The Chlamydia type III effector TarP alters the dynamics and organization of host cell focal adhesions

This study shows that Chlamydia's effector TarP stabilizes focal adhesions by interacting with vinculin, reducing cell motility and enhancing matrix attachment.