A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator
A. Zaalberg, E. Minnee, I. Mayayo-Peralta, K. Schuurman, S. Gregoricchio, T. A. van Schaik, L. Hoekman, D. Li, E. Corey, H. Janssen, C. Lieftink, S. Prekovic, M. Altelaar, P. S. Nelson, R. Beijersbergen, , A. M. Bergman
This study uses a CRISPR screen to identify genes critical for macrophage-mediated killing of prostate cancer cells, revealing AR as an immunomodulator that promotes resistance to macrophage attack.
bioRxiv · Jun 6, 2023Cancer Biology