D. Li

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

HLA-E-VL9 antibodies enhance NK cell and CD8+ T cell cytotoxicity against HIV-infected CD4+ T cells

This study develops anti-HLA-E-VL9 antibodies that enhance NK and CD8+ T cell cytotoxicity against HIV-infected cells by blocking NKG2A/CD94 interactions and promoting ADCC.

Promiscuous NAD-dependent dehydrogenases enable efficient bacterial growth on the PET monomer ethylene glycol

This study identifies NAD-dependent dehydrogenases in Paracoccus denitrificans that enable efficient bacterial growth on ethylene glycol, with implications for biotechnological applications.

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

CAMSAP3 Forms Dimers via its lapha-helix Domain that Directly Stabilize Non-centrosomal Microtubule Minus Ends

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

This study shows gut microbiome dysbiosis in mice increases Mycobacterium tuberculosis lung colonization by altering Nos2 pathways via the gut-lung axis.

Evolutionary analysis of paired box gene family and biological function exploration of Lr.Pax7 in lamprey (Lethenteron reissneri)

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

Time-lapse Image Super-resolution Neural Network with Reliable Confidence Quantification for Optical Microscopy

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut

This paper develops an ingestible, battery-free robotic interface for chronic gut electrostimulation, showing it can modulate ghrelin levels and has potential for treating gastrointestinal conditions.

Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy

This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.

Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1

This study shows that BRG1 activity fluidizes the nucleus, altering its stiffness and dissipating mechanical energy, with implications for nuclear mechanics and remodeling.

Microbial Analysis and Sanitization of Hydroponic Farming Facilities in Singapore

This study identifies biofilm-forming bacteria in hydroponic systems and evaluates sanitization solutions, finding sodium hypochlorite most effective for biofilm removal.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discovery

This paper introduces TEAQ, a software tool that selects clinical-grade biomarker candidates from DIA-MS data by evaluating protein quantification metrics in a discovery cohort.

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.

This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

This study overexpresses PpGL2 in soybean to improve drought tolerance, showing reduced oxidative stress and enhanced growth under drought conditions.

Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma

This study examines the spatial organization of dendritic cell (DC) subsets and their interactions with CD8+ T cells in melanoma patients, finding that proximity between cDC1 and CD8+ T cells correlates with response to immune checkpoint inhibitors.

Transcranial Photobiomodulation on the Left Prefrontal Cortex Enhances Mandarin Chinese L1 and L2 Complex Sentence Processing Performances

This study shows that transcranial photobiomodulation over the left prefrontal cortex improves sentence processing in Mandarin Chinese L1 and L2 speakers without affecting working memory.

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

Recognition and localization of maize leaves in RGB images based on Point-Line Net

This paper develops Point-Line Net, a deep learning method for detecting maize leaves and roots in field images, achieving 81.5% object detection accuracy and 33.5% keypoint detection performance.

Genomic and transcriptomic characteristics of type VI secretion system in Klebsiella pneumoniae

This study analyzes the genomic and transcriptomic features of the Type VI secretion system (T6SS) in Klebsiella pneumoniae, showing its presence in all clinical isolates and its role in interbacterial competition.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

Distinct Roles of Kif6 and Kif9 in Mammalian Ciliary Trafficking and Motility

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.