Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections - Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils
N. Aaltonen, P. Singha, H. Jakupovic, T. Wirth, H. Samaranayake, S. Pasonen-Seppanen, K. Rilla, M. Varjosalo, L. Edgington-Mitchell, P. Kasperkiewicz, M. Drag, S. Kalvala, E. Moisio, J. R. Savinainen, J. T. Laitinen
The paper introduces tissue-ABPP, a method for high-resolution imaging of serine hydrolase activity in tissue sections, revealing activity hotspots in glioma tumors linked to neutrophils.
bioRxiv · Sep 26, 2019Cancer Biology