Author

T. Wirth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Tristan· 2 shared C.-A. Gustave· 2 shared F. Laurent· 2 shared F. Vandenesch· 2 shared J.-P. Rasigade· 2 shared A. Lautwein· 1 shared B. Sebastian· 1 shared C. Bourg· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

A. Tristan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Potential role of Mercury pollutants in the success of Methicillin-Resistant Staphylococcus aureus USA300 in Latin America

C.-A. Gustave, J.-P. Rasigade, P. Martins Simoes, F. Couzon, C. Bourg, A. Tristan, F. Laurent, T. Wirth, F. Vandenesch

The paper investigates how mercury pollution may contribute to the dominance of a USA300 variant in South America by enhancing its fitness under mercury exposure.

bioRxiv · Jul 1, 2020 · PreprintMicrobiology

Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections - Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils

N. Aaltonen, P. Singha, H. Jakupovic, T. Wirth, H. Samaranayake, S. Pasonen-Seppanen, K. Rilla, M. Varjosalo, L. Edgington-Mitchell, P. Kasperkiewicz, M. Drag, S. Kalvala, E. Moisio, J. R. Savinainen, J. T. Laitinen

The paper introduces tissue-ABPP, a method for high-resolution imaging of serine hydrolase activity in tissue sections, revealing activity hotspots in glioma tumors linked to neutrophils.

bioRxiv · Sep 26, 2019Cancer Biology

ω-imidazolyl-alkyl derivatives as new preclinical drug candidates for NASH therapy

T. Diesinger, A. Lautwein, V. Buko, E. Belonovskaya, O. Lukivskaya, E. Naruta, S. Kirko, V. Andreev, R. Dvorsky, D. Buckert, B. Sebastian, C. Renz, D. Müller-Enoch, T. Wirth, T. Haehner

The paper tests two new CYP2E1 inhibitors, I-ol and I-an, in a rat model of NASH, finding they reduce pathological markers and show good tolerability.

bioRxiv · Jun 28, 2019 · PreprintPharmacology & Toxicology

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

M. Merker, M. Barbier, H. Cox, J.-P. Rasigade, S. Feuerriegel, T. A. Kohl, R. Diel, S. Borrell, S. Gagneux, V. Nikolayevskyy, S. Andres, U. Nübel, P. Supply, T. Wirth, S. Niemann

The paper investigates the evolutionary mechanisms behind multidrug-resistant tuberculosis in Central Asia, finding that compensatory mutations enhance resistance and transmission success.

bioRxiv · May 31, 2018Evolutionary Biology

Demographic fluctuation of community-acquired antibiotic-resistant Staphylococcus aureus lineages: potential role of flimsy antibiotic exposure

C.-A. Gustave, A. Tristan, P. Martins-Simoes, M. Stegger, Y. Benito, P. S. Andersen, M. Bes, P. Glaser, F. Laurent, T. Wirth, F. Vandenesch

The paper investigates how low-level antibiotic exposure influences the expansion of two CA-MRSA lineages by reversing the fitness cost of antibiotic resistance.

bioRxiv · Oct 19, 2017Microbiology