HUMAN PANCREATIC CANCER CELLS UNDERGO PROFOUND METABOLIC REPROGRAMMING TOWARDS CELLULAR STEMNESS AS ADAPTATION TO INHIBITION OF THE AKT PATHWAY
H. Arasanz, C. Hernandez, A. Bocanegra, L. Chocarro, M. Zuazo, M. Gato, K. Ausin, E. Santamaria, J. Fernandez, G. Fernandez, E. Monasterio, C. Rodriguez, I. Blanco, R. Vera, D. Escors, G. Kochan
This study shows that pancreatic cancer cells adapt to AKT pathway inhibition by reprogramming metabolism and acquiring stemness traits, which can be targeted with combined therapy.
bioRxiv · Apr 1, 2020 · PreprintCancer Biology