J. Fernandez

A murine experimental model of the unique pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus

This paper develops a mouse model of thrombosis induced by Bothrops lanceolatus venom, showing juvenile venom causes more pulmonary thrombi despite similar proteomes to adult venom.

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

A polarized cell system amenable to subcellular resolution imaging of influenza virus infection

This paper describes a 3D cell culture method to study influenza virus infection in polarized cells with subcellular resolution.

Cross-species transmission and PB2 mammalian adaptations of highly pathogenic avian influenza A/H5N1 viruses in Chile

The paper tracks the emergence and mammalian adaptation of H5N1 HPAIV in Chile, identifying key mutations in the PB2 gene associated with cross-species transmission.

Pharmacogenomics of GLP-1 Receptor Agonists: A genome-wide analysis of observational data and large randomized controlled trials

This study identifies genetic variants associated with glycaemic response to GLP-1 receptor agonists using observational and trial data, finding variants in GLP-1R and ARRB1 linked to HbA1c reduction.

Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.

This study optimizes peptaibol production from Trichoderma asperellum and evaluates its antifungal activity against plant pathogens, showing high inhibition rates and disease prevention in tomatoes.

C-di-GMP signalling links biofilm formation and Mn(II) oxidation in Pseudomonas resinovorans.

This paper identifies c-di-GMP signaling as a regulator linking biofilm formation and Mn(II) oxidation in Pseudomonas resinovorans, showing its role in up-regulating Manganese-Oxidizing Peroxidase (MOP) expression and influencing Mn oxide accumulation patterns.

One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment

This study models Klebsiella transmission across human, animal, and environmental sources, finding limited AMR spread outside clinical settings and human-to-human transmission dominance.

Identical Sequences, Different Behaviors: ProteinDiversity Captured at the Single-Molecule Level

This paper introduces a magnetic tweezers technique to measure single-molecule protein folding dynamics over days, revealing molecular diversity through force response and folding kinetics.

Role of two metacaspases in development and pathogenicity of the Rice Blast fungus, Magnaporthe oryzae

This study identifies two metacaspases in Magnaporthe oryzae that regulate fungal growth, development, and stress responses, contributing to pathogenicity.

Structures of an intact yeast V-ATPase alone and in complex with bacterial effector VopQ

This study reports cryo-EM structures of the intact yeast V-ATPase and its complex with the bacterial effector VopQ, revealing interactions and catalytic conformations.

HUMAN PANCREATIC CANCER CELLS UNDERGO PROFOUND METABOLIC REPROGRAMMING TOWARDS CELLULAR STEMNESS AS ADAPTATION TO INHIBITION OF THE AKT PATHWAY

This study shows that pancreatic cancer cells adapt to AKT pathway inhibition by reprogramming metabolism and acquiring stemness traits, which can be targeted with combined therapy.

Exploiting evolutionary herding to control drug resistance in cancer

This paper demonstrates evolutionary herding in non-small cell lung cancer to control drug resistance by shifting clonal composition and inducing collateral sensitivity.

Nucleolin internalizes Bothrops asper Lys49 phospholipase A2 forming cell surface amyloid-like assemblies

This paper shows that Bothrops asper Lys49 phospholipase A2 interacts with nucleolin, is internalized by cells via nucleolin, and forms amyloid-like surface assemblies that may drive toxicity.