C. Rodriguez

Lower Airway Dysbiosis in NTM+ Bronchiectasis is Associated with NET-Predominant Severe Phenotypes

This study links lower airway microbiota and neutrophilic inflammation in NTM+ bronchiectasis to severe disease phenotypes through network analysis and preclinical models.

Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy

This study uses third-harmonic generation microscopy to image plant roots and microbes in their natural environment without labels.

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

Tissue damage during acute Trypanosoma cruzi infection is associated with reduced reparative regulatory T cell response and can be attenuated by early interleukin-33 administration.

This study shows that reduced trTregs during T. cruzi infection correlates with tissue damage, and early IL-33 treatment increases trTregs and reduces damage.

CD39 expression by regulatory T cells drives CD8+ T cell suppression during experimental Trypanosoma cruzi infection

This study shows that CD39 expression on regulatory T cells suppresses CD8+ T cell responses during Trypanosoma cruzi infection, highlighting its role in immune regulation.

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

Vitamin D deficiency induces erectile dysfunction: role of superoxide

This study shows vitamin D deficiency causes erectile dysfunction by increasing superoxide production in penile tissue.

Direct measurements of luminal Ca2+ with endo-lysosomal GFP-aequorin (ELGA) reveal functional IP3 receptors

The paper uses a modified aequorin probe to measure Ca2+ in endo-lysosomes, revealing IP3-sensitive Ca2+ stores and functional IP3 receptors in this compartment.

A Unique Polyfunctional IL-33-responsive ST2⁺ NK cell State Potentiates Antitumor Immunity and Response to Immunotherapy

The paper identifies a unique ST2+ NK cell state that enhances antitumor immunity and response to immunotherapy through IL-33 and IL-12 signaling.

CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

The paper identifies CD39+ CD4+ T cells in tumors with exhaustion and cytotoxic traits, showing their expansion with CTLA-4 blockade and association with better survival in breast cancer.

Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells

Physiological state matching in a pair bonded poison frog

The paper investigates emotional contagion in poison frogs, finding physiological state-matching between male and female partners, independent of behavioral or reproductive factors.

Acai (Euterpe precatoria Mart. Arecaceae) from the Northern Region of Bolivia is not contaminated with Trypanosoma cruzi

The paper tests Bolivian acai for Trypanosoma cruzi contamination and finds no presence of the parasite in fresh or frozen acai pulps.

Poison frog chemical defense are influenced by environmental availability and dietary selectivity for ants

This study investigates how environmental availability and dietary selectivity for ants influence chemical defenses in poison frogs.

Contrasting parental roles shape sex differences in poison frog space use but not navigational performance

This study examines sex differences in poison frog spatial behavior and finds that parental roles influence space use but not navigational performance, challenging the adaptive specialization hypothesis.

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

This study examines the fusogenicity and neutralization sensitivity of the SARS-CoV-2 AY.4.2 sublineage compared to the Delta variant, finding similar spike function but reduced neutralization sensitivity to certain antibodies and vaccines.

A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates

This study analyzes 21 years of E. coli bloodstream infections in a hospital, showing how community and hospital dynamics of B2 phylogroup clones influence BSI rates.

Estimated quantity of swine virus genomes based on quantitative PCR analysis in spray-dried porcine plasma samples collected from multiple manufacturing plants.

The paper estimates viral contamination levels in porcine plasma samples using qPCR, finding low viral loads and regional strain variations.

Identification of CRF66_BF, a new HIV-1 circulating recombinant form of South American origin

The paper identifies CRF66_BF, a new HIV-1 circulating recombinant form of South American origin, distinct from CRF12_BF and prevalent in Paraguay.

Pharmacokinetic Effects of Combined Exposure to Nicotine and THC via E-Cigarettes in Pregnant Rats

This study examines the physiological effects of combined nicotine and THC exposure via e-cigarettes in pregnant rats, finding altered drug levels and temperature changes.

A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile

This study analyzes 10,330 C. difficile genomes to map antimicrobial resistance (AMR) across the species, identifying AMR determinants, their distribution, and associations with specific strains and regions.

Prenatal Alcohol and THC E-Cigarette Exposure Effects on Motor Development

This study examines the effects of prenatal alcohol and THC e-cigarette exposure on motor development in rats, finding delayed sensorimotor development from THC alone and hyperactivity from combined exposure.

Are some commercial diets inadequate in essential nutrients?

This study evaluates two commercial diets for essential nutrient adequacy, finding both lack full compliance but diet 1 is more sustainable with modifications.

Neutralization heterogeneity of United Kingdom and South-African SARS CoV-2 variants in BNT162b2-vaccinated or convalescent COVID-19 healthcare workers

The study assesses neutralizing antibody potency against UK and SA SARS-CoV-2 variants in vaccinated and convalescent healthcare workers, finding reduced neutralization against SA variants in some convalescents.

Neutralizing antibodies targeting the SARS-CoV-2 receptor binding domain isolated from a naïve human antibody library

The paper isolates and characterizes three novel neutralizing antibodies against SARS-CoV-2 RBD from a naive human antibody library, showing they neutralize the virus in vitro.

Clostridium perfringenosum sp. nov., a closely related species toClostridium perfringens and its virulence factors, isolated from a humansoft tissue infection

This paper describes the discovery of a new Clostridium species, C. perfringenosum, closely related to C. perfringens, based on genomic and phenotypic analyses of isolates from a human infection.

An adaptive optics module for deep tissue multiphoton imaging in vivo

This paper develops an adaptive optics module for multiphoton imaging in vivo, enabling high-resolution visualization of neural structures and calcium responses in deep brain and spinal cord regions of mice.

Androgen responsiveness to simulated territorial intrusions in Allobates femoralis males: evidence supporting the challenge hypothesis in a territorial frog

The study tests the Challenge Hypothesis in Allobates femoralis frogs by measuring androgen responses to simulated territorial intrusions, finding a positive correlation between intrusions and androgen levels.

The Clostridioides difficile species problem: global phylogenomic analysis uncovers three ancient, toxigenic, genomospecies

This study identifies three ancient, toxigenic genomospecies within C. difficile using global phylogenomic analysis, reshaping its taxonomy and understanding of toxin gene evolution.

HUMAN PANCREATIC CANCER CELLS UNDERGO PROFOUND METABOLIC REPROGRAMMING TOWARDS CELLULAR STEMNESS AS ADAPTATION TO INHIBITION OF THE AKT PATHWAY

This study shows that pancreatic cancer cells adapt to AKT pathway inhibition by reprogramming metabolism and acquiring stemness traits, which can be targeted with combined therapy.