Drinking-Water 4,4'-Methylenedianiline Establishes a Longitudinally Tractable Mouse Model of Cholestatic Liver Injury
T. Iwasaka, K. Morita, I. Azuma, T. Nakagawa, E. Nakashima, T. Kamei, Y. Kato, H. Kusuhara, T. Mizuno
This paper develops a drinking-water model of cholestatic liver injury in mice using MDA, showing sustained ALT elevation and distinct histological and biochemical features compared to TAA-DW.
bioRxiv · Jan 25, 2024 · PreprintPharmacology & Toxicology