K. Morita

This paper develops a drinking-water model of cholestatic liver injury in mice using MDA, showing sustained ALT elevation and distinct histological and biochemical features compared to TAA-DW.

The paper identifies novel subgroups in myeloid malignancies using a network-based clustering approach that integrates genomic and clinical features, improving prognostic accuracy.

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

This study introduces Rmg8 into a wheat cultivar to create near-isogenic lines resistant to wheat blast at both seedling and heading stages, showing broader resistance than existing genetic resources.

This study examines the biology of rainbow trout in Lake Chinishibetsu's inlet tributaries, finding continuous reproduction and a dimorphic life history with river residents and lake migrants.

This study determines the cryo-EM structure of Tanay virus and reveals its dynamic shape changes under different conditions, suggesting structural roles in infection and assembly.

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

The paper examines how genetic variation magnitude influences evolutionary rescue through ecological and reproductive character displacement, finding that reproductive displacement relies more on additive genetic variance.

This study shows that 5-ALA inhibits SARS-CoV-2 infection in vitro in both human and non-human cells with low cytotoxicity, suggesting it as a potential oral antiviral drug for COVID-19.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.