PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
R. Crespo, E. Ne, J. Reinders, J. I. J. Meier, C. Li, S. Jansen, A. Gorska, S. Kocer, T. W. Kan, W. Doff, D. Dekkers, J. Demmers, R. J. Palstra, S. Rao, T. Mahmoudi
This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.
bioRxiv · Sep 21, 2023Microbiology