Author

J. Demmers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

A. Ray Chaudhuri· 2 shared C. Mukherjee· 2 shared H. Lans· 2 shared J. Marteijn· 2 shared K. Bezstarosti· 2 shared M. van Toorn· 2 shared A. d'Azzo· 1 shared A. Gorska· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

A. Ray Chaudhuri

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

R. Crespo, E. Ne, J. Reinders, J. I. J. Meier, C. Li, S. Jansen, A. Gorska, S. Kocer, T. W. Kan, W. Doff, D. Dekkers, J. Demmers, R. J. Palstra, S. Rao, T. Mahmoudi

This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.

bioRxiv · Sep 21, 2023Microbiology

Mitochondrial proteostasis mediated by CRL5Ozz and Alix maintains skeletal muscle function

Y. Campos, R. Rodriguez-Enriquez, G. Palacios, D. Van de Vlekkert, X. Qiu, J. Weesner, E. Gomero, J. Demmers, T. Bertorini, J. T. Opferman, G. T. Grosveld, A. d'Azzo

This study identifies CRL5Ozz and Alix as regulators of mitochondrial proteostasis by controlling Slc25A4 levels, which impacts mitochondrial function and muscle fiber composition.

bioRxiv · Jul 11, 2023 · PreprintCell Biology

Functional single cell proteomic profiling of cells with abnormal DNA damage response dynamics

P.-R. Su, L. You, C. Beerens, K. Bezstarosti, J. Demmers, M. Pabst, R. Kanaar, C.-C. Hsu, M.-P. Chien

The paper develops FUNpro, a functional single-cell proteomic profiling method, to link proteomes with dynamic cellular phenotypes, identifying PDS5A and PGAM5 in DDR survival.

bioRxiv · Oct 13, 2021 · PreprintBioengineering

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

M. Geijer, D. Zhou, K. Selvam, B. Steurer, B. Evers, C. Mukherjee, S. Cugusi, M. van Toorn, M. van der Woude, W. Gong, R. Janssens, A. Raams, J. Lebbink, B. Geverts, D. Plummer, , J. Marteijn

This study identifies ELOF1 as a factor that promotes transcription-coupled repair and prevents genome instability by modulating transcription and recruiting repair factors.

bioRxiv · May 11, 2021Cell Biology

SMARCAD1 Mediated Active Replication Fork Stability Maintains Genome Integrity

C. Lo, M. van Toorn, V. Gaggioli, M. Paes Dias, Y. Zhu, E. Maria Manolika, W. Zhao, M. van der Does, C. Mukherjee, J. Souto Goncalves, M. van Royen, P. French, J. Demmers, I. Smal, H. Lans, , N. Taneja

This study identifies SMARCAD1 as a critical factor for replication fork stability, showing its role in preventing genome instability and enhancing resistance to replication poisons.

bioRxiv · Oct 5, 2020Cell Biology