Combination EZH2 inhibition and retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
E. OBrien, C. Tse, I. Tracy, I. Reddin, J. Selfe, J. Gibson, W. Tapper, R. J. Pengelly, J. Gao, E. Aladowicz, G. Petts, K. Thway, S. Popov, A. Kelsey, T. J. Underwood, , Z. S. Walters
This study shows that combining EZH2 inhibition with retinoic acid treatment reduces RMS cell proliferation by inducing apoptosis or differentiation depending on the RMS subtype.
bioRxiv · Jun 12, 2023 · PreprintCancer Biology