J. Gao

The fully activated open state of KCNQ1 controls the cardiac 'fight-or-flight' response

This paper identifies the fully activated open state of KCNQ1 as critical for β-adrenergic stimulation of IKs channels, showing that modulators enhancing this state can restore function in LQT1 mutants.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase

This study identifies the Hel2i domain as essential for FANCM's DNA binding and branch migration, revealing its role in suppressing the ALT pathway in cancer cells.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Flat-field superresolution structured illumination microscopy with joint temporal-spatial light modulation

This paper introduces a flat-field structured illumination microscopy method to improve field uniformity and enable large-scale imaging of whole cells and pathological samples.

Propofol overcome Tamoxifen resistance in breast cancer by modulating tumorogenesis, immune response and metabolism

This study shows Propofol overcomes Tamoxifen resistance in breast cancer by inducing cell cycle arrest, apoptosis, and altering gene expression related to cell cycle, immune response, and metabolism.

Scalable primordial germ cell-like-cell platform for functional genomics identifies epigenetic fertility modifiers

This paper develops a scalable method to generate PGC-like cells and uses it to identify epigenetic factors affecting germline development.

Differences in milk microbiota between healthy cows and cows with recurring Klebsiella mastitis

The paper compares milk microbiota between healthy cows and those with recurring Klebsiella mastitis, finding differences in bacterial genera associated with infection.

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

A 'shock-and-lock' nanoparticle agonist activates STING in type 1 conventional dendritic cells to enhance antitumor immunity with associated biomarkers.

DomainFit: Identification of Protein Domains in cryo-EM maps at Intermediate Resolution using AlphaFold2-predicted Models

DomainFit identifies protein domains in low-resolution cryo-EM maps using AlphaFold2 models, revealing new proteins in cellular complexes.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Mechanisms analysis for Formononetin counteracted-Osimertinib resistance in Non-small-cell lung cancer cells: from the insight into the gene transcriptional level

This study investigates how Formononetin reverses Osimertinib resistance in NSCLC cells by analyzing gene expression changes.

The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

This study identifies the αC-β4 loop as a key regulator of allosteric cooperativity between nucleotide and substrate in PKA-C through simulations and mutagenesis experiments.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

Functional analysis of cyclic diguanylate-modulating proteins in Vibrio fischeri

This study systematically characterizes the functional roles of 50 c-di-GMP-modulating proteins in Vibrio fischeri during lifestyle transitions.

Combination EZH2 inhibition and retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

This study shows that combining EZH2 inhibition with retinoic acid treatment reduces RMS cell proliferation by inducing apoptosis or differentiation depending on the RMS subtype.

Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity

The paper identifies mutations in phage virion assembly proteins that enable evasion of Type I CBASS immunity by altering infection kinetics.

Modernizing the original influenza vaccine to enhance protective antibody responses against neuraminidase antigens

This study enhances influenza vaccine efficacy by improving NA antibody responses through modified virions and recombinant NA proteins in a mouse model.

Bioengineering of a Lactococcus lactis subsp. lactis strain enhances nisin production and bioactivity.

This study enhances nisin production and antimicrobial activity in Lactococcus lactis subsp. lactis through genetic modifications involving nisA, nisRK, and nisZ genes.

Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells

This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.

PrioriTree: a utility for improving phylodynamic analyses in BEAST

PrioriTree helps researchers assess prior sensitivity in discrete-geographic phylodynamic models by generating BEAST input files and summarizing outputs for robust Bayesian inference.

Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

This study identifies and evaluates LFS-1107, a CRM1 inhibitor that suppresses ENKTL cell growth by blocking NF-κB signaling and shows promise for clinical translation.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Comparative genomic analyses of Lactococcus garvieae isolated from bovine mastitis in China

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

Osteocytes regulate organismal senescence of bone and bone marrow

This study shows that osteocyte ablation in mice leads to senescence-associated changes in bone and bone marrow lineages, causing sarcopenia, osteoporosis, and shortened lifespan.

Visualizing the stochastic gating of Na+/H+ antiporters in single native bacteria

This study observes and attributes intermittent bioluminescence blinking in native bacteria to stochastic gating of Na+/H+ antiporters, revealing their dynamic behavior in living cells.