A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression.
R. C. A. Sainson, A. K. Thotakura, M. Kosmac, G. Borhis, N. Parveen, R. Kimber, J. Carvalho, S. Henderson, K. Pryke, T. Okell, S. O'Leary, S. Ball, L. Gamand, E. Taggart, E. Pring, , M. McCourt
This paper develops an antibody targeting ICOS that improves the TEFF:TReg ratio and induces tumour regression in preclinical models.
bioRxiv · Sep 16, 2019 · PreprintCancer Biology