HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis
C. Comert, K. Kjaer-Sorensen, J. Hansen, J. Carlsen, J. Just, B. F. Meany, E. Oestergaard, Y. Luo, C. Oxvig, L. Schmidt-Laursen, J. Palmfeldt, P. Fernandez-Guerra, P. Bross
This study investigates how HSP60 deficiency disrupts mitochondrial proteostasis and dysregulates cholesterol synthesis, leading to developmental abnormalities and hypomyelination.
bioRxiv · Jan 31, 2024Cell Biology