Mismatch-repair signature mutations activate gene enhancers across colorectal cancer epigenomes
S. Hung, A. Saiakhova, Z. Faber, C. F. Bartels, D. Neu, I. Bayles, E. Ojo, E. S. Hong, W. D. Pontius, A. R. Morton, R. Liu, M. F. Kalady, D. N. Wald, S. Markowitz, P. C. Scacheri
The paper identifies MMR signature mutations in colorectal cancer that activate enhancers by increasing FOX factor affinity and promoting tumor growth.
bioRxiv · Sep 7, 2018Cancer Biology